It is not intended to be a substitute for the advice of a medical expert.ChromeMate is a patented form of the mineral chromium bound to niacin. Since the tolerable upper intake level has not been established, it would be best to take the supplements under medical supervision.ĭisclaimer: The information provided in this article is solely for educating the reader. However, diabetics should consider a high-dose chromium supplementation, only if it is recommended by their healthcare provider. According to the results of a few controlled clinical trials, toxic effects were not observed when 200-1000 mcg of chromium was taken daily in divided doses for several months. On the other hand, various studies have suggested that the niacin-bound form of chromium is well-assimilated. Though there have been isolated reports of kidney or liver problems in case of individuals taking chromium picolinate, a cause-effect relationship could not be proved in the absence of scientific evidence. There are contradictory reports on the effect of these supplements in case of people affected by depression, anxiety, or schizophrenia. Since the niacin-bound chromium helps in regulating the levels of insulin, taking these supplements with insulin might lower the blood sugar levels, thereby making one susceptible to hypoglycemia. Taking the supplements with NSAIDs can increase chromium levels, whereas these supplements can adversely affect the absorption of levothyroxine or synthetic thyroid hormone. There could be adverse drug interactions if the supplements are taken in combination with anti-inflammatory drugs or levothyroxine. Caution must be exercised when the supplements are taken in combination with the drugs for diabetes. ![]() ![]() Since there isn’t any conclusive evidence to support the aforementioned risk, the best option is to consult one’s healthcare provider about the right dosage. To add to that, the Institute of Medicine has not established a tolerable upper intake level, which is the maximum daily intake of a nutrient that is unlikely to cause adverse health effects. However, these claims are yet to be substantiated with concrete scientific evidence due to the absence of large, controlled clinical trials. Concerns were raised regarding the long-term safety of the latter, after a study linked its use to possible DNA damage. They are considered to be the safer form with better bioavailability in comparison to chromium picolinate (CR-P), which is the form of chromium that is bound to picolinic acid. The niacin or nicotinic acid-bound chromium (Cr-N) supplements are widely used, as these have not been associated with toxicity. Ann de Wees Allen, the niacin-bound form is 672% and 311% better absorbed than chromium chloride and chromium picolinate respectively.Ĭhromium Polynicotinate Vs. ![]() The absorption rate of niacin-bound chromium polynicotinate is believed to be higher than the other two forms. The common supplemental sources include chromium chloride, chromium picolinate, and chromium polynicotinate. Generally, chromium supplementation or the inclusion of its dietary sources (whole grains, eggs, cheese, liver, lean meats, and brewer’s yeast) is recommended for treating its deficiency. Chromium losses might also increase in the event of physical stress, trauma, or acute infections. This is mainly attributed to the fact that processing of food leads to the removal of up to 80% of the chromium in foods. Though chromium is an essential trace element that is required in small amounts for the healthy functioning of the body, the incidence of chromium deficiency is quite high. Caution must be exercised by diabetics who are taking chromium supplements, as these can interact with the medication for diabetes, thereby increasing the risk of hypoglycemia. It is believed that chromium’s influence on insulin metabolism might be due to its interaction with a protein called low molecular weight chromium-binding substance (LMWCr).
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